個(gè)人簡(jiǎn)介：

孫鈺椋，男，講師，碩士生導(dǎo)師。2024年畢業(yè)于馬來西亞理科大學(xué)生物醫(yī)學(xué)專業(yè)?，F(xiàn)就職于新鄉(xiāng)醫(yī)學(xué)院醫(yī)學(xué)工程學(xué)院干細(xì)胞與生物治療國(guó)家地方聯(lián)合工程實(shí)驗(yàn)室。主要從事間充質(zhì)干細(xì)胞的基因修飾相關(guān)研究工作。第一作者在 Cell Death & Disease, Materials Today Bio等雜志發(fā)表SCI論文5篇。參與國(guó)家自然科學(xué)基金1項(xiàng)。

聯(lián)系方式：

新鄉(xiāng)醫(yī)學(xué)院北校區(qū)科技樓3樓

E-mail：xiaonanjie2dong@163.com

研究方向：

間充質(zhì)干細(xì)胞的智能化修飾

間充質(zhì)干細(xì)胞外泌體的靶向修飾

招生方向：

專業(yè)學(xué)位碩士（專碩）：生物醫(yī)藥

教育經(jīng)歷

2012.09至2016.06    湖北民族大學(xué)       生物工程     本科       

2016.09至2019.06    新鄉(xiāng)醫(yī)學(xué)院         生物學(xué)       碩士

2021.09至2024.10    馬來西亞理科大學(xué)   生物醫(yī)學(xué)     博士

項(xiàng)目課題

國(guó)家自然科學(xué)基金聯(lián)合項(xiàng)目，《經(jīng)血源性子宮內(nèi)膜干細(xì)胞通過調(diào)控調(diào)節(jié)性免疫細(xì)胞對(duì)神經(jīng)自體免疫疾病的干預(yù)機(jī)制研究》，2019/01-2021/12，結(jié)項(xiàng)，參與。

代表性論文：

1. Yuliang Sun, Wenlong Zhang, Yilin Lu, Yanan He, Badrul Yahaya, Yanli Liu, Juntang Lin. An Artificial Signaling Pathway Primitive-based Intelligent Biomimetic Nanoenzymes Carrier Platform for Precise Treatment of Her2 (+) tumors. Materials Today Bio, 2024, 26:101105. (第一作者，IF=8.7, 中科院1區(qū)).

2. Yuliang Sun, Yilin Lu, Xinze Li, Yanan He, Then Kong Yong, Cheong Soon Keng, Badrul Yahaya, Yanli Liu, Juntang Lin. Intelligent drugs based on notch protein remodeling: a defensive targeting strategy for tumor therapy. Cell Death & Disease, 2024,15(8):632. (第一作者，IF=8.1, 中科院1區(qū)).

3. Yuliang Sun, Lingrui Shang, Ruihong Liu, Xinyi Li, Shenghui Zhang, Yakun Ren, Kang Fu, Hongbin Cheng, Badrul Yahaya, Yanli Liu, Juntang Lin. Therapeutic effects of menstrual blood-derived endometrial stem cells on mouse models of streptozotocin-induced type 1 diabetes. World J Stem Cells, 2022, 14(1):104. (第一作者，IF=4.1, 中科院3區(qū))

4. Yuliang Sun, Yakun Ren, Fen Yang, Yanan He, Shengying Liang, Lihong Guan, Fangfang Cheng, Yanli Liu, Juntang Lin. High-yield isolation of menstrual blood-derived endometrial stem cells by direct red blood cell lysis treatment. Biol Open, 2019, 8(5). (第一作者，IF=2.0, 中科院4區(qū))

5. Yanan He, Yuliang Sun, Yakun Ren, Liang Qiao, Rui Guo, Jiang Du, Xinxing Zhu, Yanli Liu, Juntang Lin. The T cell activating properties and antitumour activity of Staphylococcal Enterotoxin-like Q. Med Microbiol Immunol, 2019. (共同一作, IF=1.9,中科院3區(qū))

6. 孫鈺椋，楊記超，何亞南，任雅坤，喬梁，劉彥禮，林俊堂. C1 型尼曼-匹克氏癥小鼠免疫系統(tǒng)功能異常初步研究.中華微生物學(xué)和免疫學(xué)雜志， 2018,38(10):739-747. （第一作者，中華系列雜志）

7. Yilin Lu, Ruihong Liu, Xingpeng Kang, Shenghui Zhang, Yuliang Sun, Wenqiang Fan, Hongbin Cheng, Yanli Liu, Juntang Lin. Menstrual Blood-Derived Endometrial Stem Cell Transplantation Improves Male Reproductive Dysfunction in T1D Mice by Enhancing Antioxidative Capacity. Reprod Sci, 2024, 31(6):1719-1731. (IF=2.6, 中科院3區(qū))

8. Zhihao Xu, Guoqing Zhang, Xiaoyue Zhang, Yu Lei, Yuliang Sun, Yanan He, Fen Yang, Wenbin Nan, Xuekun Xing, Yonghai Li, Juntang Lin. Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway. Int J Biochem Cell Biol, 2023, 157:106386. (IF=3.4, 中科院3區(qū))

9. Lingrui Shang, Ruiyun Zhang, Jiaxing Yan, Yilin Lu, Shenghui Zhang, Yuliang Sun, Hongbin Cheng, Yanli Liu, Juntang Lin. Sustainable Production and Activity Determination of Serum-Free Conditioned Medium from Menstrual Blood-Derived Endometrial Stem Cells. Appl Biochem Biotechnol, 2023, 195(2):1109-1121. (IF=3.1, 中科院4區(qū))

10. Tongtong Chen, Shenghui Zhang, Hongzhang Jin, Xiaofei Fu, Lingrui Shang, Yilin Lu, Yuliang Sun, Badrul Yahaya, Yanli Liu, Juntang Lin. Nonfreezing Low Temperature Maintains the Viability of Menstrual Blood-Derived Endometrial Stem Cells Under Oxygen-Glucose Deprivation Through the Sustained Release of Autophagy-Produced Energy. Cell Transplant, 2022. (IF=3.3, 中科院4區(qū))

11. Yanli Liu, Shengying Liang, Fen Yang, Yuliang Sun, Lidan Niu, Yakun Ren, Hongmei Wang, Yanan He, Jiang Du, Jun Yang, Juntang Lin. Biological characteristics of endometriotic mesenchymal stem cells isolated from ectopic lesions of patients with endometriosis. Stem Cell Res Ther, 2020, 11(1):346.  (IF=6.8, 中科院2區(qū))

12. Yanli Liu, Rongcheng Niu, Fen Yang, Yan Yan, Shengying Liang, Yuliang Sun, Ping Shen, Juntang Lin. Biological characteristics of human menstrual blood‐derived endometrial stem cells. J Cell Mol MedJ, 2018, 22(3):1627-1639.  (IF=4.7, 中科院2區(qū))

13. Shenghui Zhang, Yuliang Sun, Dongli Jiang, Tongtong Chen, Ruihong Liu, Xinyi Li, Yilin Lu, Liang Qiao, Ying Pan, Yanli Liu, Juntang Lin. Construction and Optimization of an Endometrial Injury Model in Mice by Transcervical Ethanol Perfusion. Reprod Sci, 2021, 28(3):693-702. (IF=2.9, 中科院1區(qū))

14. Zhihao Xu, Wenbin Nan, Xiaoyue Zhang, Yuliang Sun, Jichao Yang, Kecheng Lu, Yalin Liu, Yaoxin Gao, Fen Yang, Wenchao Mao, Xuekun Xing, Jiang Du, Han Li, Yonghai Li, Huigen Feng, Zhiqing Yuan, Juntang Lin. Umbilical cord mesenchymal stem cells conditioned medium promotes Aβ25-35 phagocytosis by modulating autophagy and Aβ-degrading enzymes in BV2C cells. J Mol Neurosci. 2018, 65(2):222-233. (IF=2.6, 中科院4區(qū))