于海川,1979.02-,2011年于北京協(xié)和醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)研究所取得博士學(xué)位,研究方向?yàn)檎婧嘶虮磉_(dá)調(diào)控。2012年加拿大Dalhousie University進(jìn)行博士后研究工作。榮獲河南省高??萍紕?chuàng)新人才,河南省教育廳學(xué)術(shù)技術(shù)帶頭人,河南省高校青年骨干教師等稱號(hào)。主持國家自然科學(xué)基金(31301135)、河南省科技創(chuàng)新人才項(xiàng)目(17HASTIT047)、河南省自然科學(xué)基金面上項(xiàng)目(162300410226)、河南省科技攻關(guān)計(jì)劃項(xiàng)目(172102310583)、河南省教育廳重點(diǎn)項(xiàng)目(14B320015)等多項(xiàng)科研項(xiàng)目,并獲得河南省博士后科研項(xiàng)目資助二等獎(jiǎng)。迄今為止在國內(nèi)外學(xué)術(shù)刊物發(fā)表論文30篇(其中SCI收錄的論文12篇);參編專著2部,授權(quán)發(fā)明專利2項(xiàng)。目前主要研究方向:1、髓系細(xì)胞造血分化相關(guān)基因表達(dá)調(diào)控;2、精神疾病相關(guān)non-coding RNA診斷標(biāo)志物的篩選;3、結(jié)核病及并發(fā)癥分子遺傳及機(jī)制研究。 發(fā)表SCI論文: Hai-chuan Yu, Jiao Wu, Hong-xing Zhang, Gao-li Zhang, Juan Sui, Wen-wen Tong, Ting-ting Qiao, Xin-ya Zhang, Li-li Nie, Ju-hong Duan, Li-rong Zhang, Lu-xian Lv. Alterations of miR-132 are novel diagnostic biomarkers in peripheral blood of schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Dec 3;63:23-9. doi: 10.1016/j.pnpbp.2015.05.007. Hai-chuan Yu, Jiao Wu, Hong-xing Zhang, Hai-san Zhang, Ting-ting Qiao, Ji-Xia Zhang, Gao-li Zhang, Juan Sui, Li-wei Li, Li-rong Zhang, Lu-xian Lv. Antidepressant-like and antioxidative efficacy of Campsis grandiflora flower. J Pharm Pharmacol. 2015 Dec;67(12):1705-15. doi: 10.1111/jphp.12466. Jiao Wu#, Haichuan Yu#, Haofu Dai, Wenli Mei, Xin Huang, Shuifang Zhu, and Ming Peng. Metabolite profiles of rice cultivars containing bacterial blight-resistant genes are distinctive from susceptible rice. Acta Biochimical et Biophysica Sinica 2012, 44: 650–659. Hai-Chuan Yu, Hua-lu Zhao Jun-Wu Zhang. Eos Negatively Regulates Human c-globin Gene Transcription during Erythroid Differentiation. PLoS ONE 2011, 6(7): e22907. doi:10.1371/journal.pone.0022907. Hai-Chuan Yu, Jiao WU, Nan-Fei XU, Ming PENG. The Role of F-box Proteins in Plant Hormone Signaling Responses. Acta Biochimical et Biophysica Sinica 2007: 39(12) 915-922. Zhang H, Wang C, Jiang T, Guo H, Wang G, Cai X, Yang L, Zhang Y, Yu H, Wang H, Jiang K. Microtubule-targetable fluorescent probe: site-specific detection and super-resolution imaging of ultratrace tubulin in microtubules of living cancer cells. Anal Chem. 2015 May 19;87(10):5216-22. doi: 10.1021/acs.analchem.5b01089. Epub 2015 May 6. Qi Cao, Kexin Zhao, Xi Zo? Zhong, Yuanjie Zou, Haichuan Yu, Peng Huang, Tian-Le Xu, and Xian-Ping Dong. SLC17A9 Protein Functions as a Lysosomal ATP Transporter and Regulates Cell Viability. J Biol Chem 2014, 289(33):23189-23199. Yan-Ni Ma, Ming-Tai Chen, Zhi-Kui Wu, Hua-Lu Zhao, Hai-Chuan Yu, Jia Yu & Jun-Wu Zhang. Emodin can induce K562 cells to erythroid differentiation and improve the expression of globin genes. Mol Cell Biochem 2013, 382:127-136, DOI 10.1007/s11010-013-1726-3. Yan-Ni Ma, Xin Zhang, Hai-Chuan Yu, Jun-Wu Zhang. CTD small phosphatase like 2 (CTDSPL2) can increase epsilon- and gamma-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood. BMC Cell Biology 2010, 11:75 doi:10.1186/1471-2121-11-75. Chunqiang Li, Baibi Zhu, Hong Chen, Zhixin Liu, Baiming Cui, Jingrui Wu, Bin Li, Haichuan Yu, Ming Peng.The Relationship between the Skeletonema Costatum Red tide and Environmental Factors in Hongsha Bay of Sanya, South China Sea. Journal of Coastal Research 2009, 25(3): 651–658. 主持科研項(xiàng)目: 項(xiàng)目名稱:Eos 對(duì)紅系分化和巨核系分化的調(diào)控作用及機(jī)制研究,主持人:于海川,課題來源:國家自然科學(xué)基金,起止日期:2014.01-2016.12.31,編號(hào):301135,金額:23 萬元; 項(xiàng)目名稱:Eos 蛋白對(duì)髓系造血細(xì)胞分化的調(diào)控作用及機(jī)制研究,課題來源:河南省高??萍紕?chuàng)新人才支持計(jì)劃,起止時(shí)間:2017.01-2019.12,項(xiàng)目編號(hào):17HASTIT04,經(jīng)費(fèi)金額:30萬元; 項(xiàng)目名稱:精神分裂癥患者外周血非編碼RNAs診斷標(biāo)志物篩選,主持人:于海川,課題來源:河南省自然科學(xué)基金面上項(xiàng)目,執(zhí)行時(shí)間:2017.01-2019.12,項(xiàng)目編號(hào):162300410226,經(jīng)費(fèi)數(shù)量:10萬元; 2016年度河南省高等學(xué)校青年骨干教師資助計(jì)劃,主持人:于海川,課題來源:河南省教育廳,項(xiàng)目編號(hào):2016GGJS-103;執(zhí)行時(shí)間:2017.01-2019.12,經(jīng)費(fèi)數(shù)量:6萬元; 項(xiàng)目名稱:miR-132作為精神分裂癥外周血標(biāo)志物的鑒定及其靶基因研究,主持人:于海川,課題來源:2014年度河南省教育廳科學(xué)技術(shù)研究重點(diǎn)項(xiàng)目,起止日期:2014.01 -2016.12,編號(hào):14B320015; 項(xiàng)目名稱:2013年度河南省博士后科研項(xiàng)目資助二等獎(jiǎng),主持人:于海川,課題來源:河南省人力資源和社會(huì)保障廳,編號(hào):51,級(jí)別:省廳級(jí),金額:6萬元; 新鄉(xiāng)醫(yī)學(xué)院精神神經(jīng)醫(yī)學(xué)學(xué)科群開放研究課題,主持人:于海川,課題來源:新鄉(xiāng)醫(yī)學(xué)院精神神經(jīng)學(xué)科群,項(xiàng)目編號(hào):2016PN-KFKT-08;執(zhí)行時(shí)間:2017.01-2019.12,經(jīng)費(fèi)數(shù)量:10萬元; 新鄉(xiāng)醫(yī)學(xué)院產(chǎn)學(xué)研合作項(xiàng)目,主持人:于海川,課題來源:新鄉(xiāng)醫(yī)學(xué)院,項(xiàng)目編號(hào):2017CXY-2-14;執(zhí)行時(shí)間:2018.01至2020 .12,經(jīng)費(fèi)數(shù)量:4萬元; 新鄉(xiāng)醫(yī)學(xué)院教育教學(xué)改革研究項(xiàng)目立項(xiàng)課題,主持人:于海川,課題來源:新鄉(xiāng)醫(yī)學(xué)院,,項(xiàng)目編號(hào):2017-XYJG-18;
參編專著: 專著名稱:天然產(chǎn)物現(xiàn)代分離技術(shù),主編:戴好富、梅文莉,副主編:吳嬌、于海川,農(nóng)業(yè)大學(xué)出版社,出版時(shí)間:2008,ISBN 7-81117-111-2. 專著名稱:醫(yī)學(xué)檢驗(yàn)概論,主編:馮書營、馮文坡,副主編:于海川、朱立強(qiáng)、梁高峰、陳瑩,科學(xué)出版社,出版時(shí)間:2016,ISBN 978-7-03-048527-4.
授權(quán)專利: 專利名稱:精神分裂癥外周血標(biāo)志物miR-132及其應(yīng)用,專利權(quán)人:于海川,吳嬌,呂路線,張紅星,李超堃,翟鵬飛,郭素芹,專利號(hào):ZL 2014 1 0533064.8,申請(qǐng)日期:2014.10.11,授權(quán)時(shí)間:2017.12.29. 專利名稱:凌霄花有效部位的制備及其抗抑郁用途,專利權(quán)人:于海川,吳嬌,隋娟,翟鵬飛,張軼,王俠,段巨洪,專利號(hào):ZL 2014 1 0763754.2,申請(qǐng)日期:2014.12.12,授權(quán)時(shí)間:2018.11.02.
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