呂壯偉
發(fā)布時間:2023-08-28 瀏覽次數(shù):

呂壯偉,男,1982年出生。博士,講師,碩士研究生導(dǎo)師,主持參與河南省科技廳、河南省教育廳等項(xiàng)目4項(xiàng),在J Mater Chem B,Oncoimmunology,Neoplasia等國際知名雜志上發(fā)表SCI論文10多篇,河南省生物物理學(xué)會理事。

聯(lián)系方式

郵箱201079@xxmu.edu.cn

學(xué)習(xí)與工作經(jīng)歷

2011.7—2016.8新鄉(xiāng)醫(yī)學(xué)院三附院檢驗(yàn)科工作

2016.9-2020.8西安交通大學(xué)基礎(chǔ)醫(yī)學(xué)院學(xué)習(xí)

2020.8至今新鄉(xiāng)醫(yī)學(xué)院法醫(yī)學(xué)院工作

研究方向

炎癥及腫瘤免疫

主要科研工作

1. 具體研究領(lǐng)域

非酒精性脂肪肝的發(fā)生機(jī)制以及腫瘤的免疫治療

2. 課題資助

(1)河南省科技攻關(guān)項(xiàng)目,212102310748,經(jīng)CD19分子將抗原MUC1和PD-L1靶向至B細(xì)胞以增強(qiáng)抗結(jié)腸癌免疫應(yīng)答機(jī)制的研究,2021-01至2022-12,0元,在研,主持結(jié)題

(2)河南省高校重點(diǎn)項(xiàng)目,22A320041,AID/JAG1在三陰性乳腺癌發(fā)展中的機(jī)制研究及其靶向應(yīng)用,2022-01至2023-12, 3萬元,在研,主持

(3)河南省自然科學(xué)基金面上項(xiàng)目,232300421189,CAR-B 細(xì)胞的建立及其抗 HER2 陽性乳腺癌的功能鑒定,2023-01至2024-12,10萬,在研,主持

3. 近期代表性論文

Zhuangwei Lv; Ping Zhang; Dandan Li; Mengting Qin; Longzhu Nie;Xiaoqian Wang; Li Ai; Zhaozu Feng; Woodvine Otineno Odhiambo; Yunfeng Ma*;Yanhong Ji*; CD19-targeting fusion protein combined with PD1 antibody enhances anti-tumor immunity in mouse models, ONCOIMMUNOLOGY, 2020, 9(1).

Junna Jiao;Zhuangwei Lv; Ping Zhang; Yang Wang; Meng Yuan; Xiaozhuo Yu; Woodvine Otieno Odhiambo; Mingzhe Zheng; Hua Zhang; Yunfeng Ma; Yanhong Ji*; AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines, NEOPLASIA, 2020, 22(3): 142-153.(并列一作)

Junna Jiao, Zhuang Qian,Yurong Wang,Mei Liu, Liye Fan, Mengqing Liu, Zichen Hao, Junrong Jiao,Zhuangwei Lv. Synthesis and Biological Evaluation of PEGylated MWO4 Nanoparticles as Sonodynamic AID Inhibitors in Treating Diffuse Large B-Cell Lymphoma. Molecules. 2022;27(21):7143.通訊作者

Junna Jiao, Kun Shao, Kaixin Wang, Jiaxuan Liu, Zhijie Weng, Junrong Jiao,Zhuangwei Lv;Universal nanosonosensitizer for ROS-mediated reduction of various cancer cells. J Mater Chem B. 2023;11(16):3703-3712.通訊作者

Jiao Junna,Lv Zhuangwei, Wang Yurong, Fan Liye, Yang Angang. The off-target effects of AID in carcinogenesis. Frontiers in Immunology 2023, 14:1221528.(并列一作)

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